Isekai anime is known for transporting its protagonists to fantastical worlds full of magic, adventure, and danger as well as for its complex and entertaining characters. While male characters often take center stage in Isekai shows, anime lovers could also meet a few laugh-out-loud funny and unforgettable female characters that make these stories truly memorable.
Fans could meet some of the funniest anime characters with unique magical powers and character designs. From quirky heroines to evil sorceresses, there are plenty of anime girls in the world of Isekai who make viewers laugh in their own special ways. While many of these hilarious characters are heroes, anime lovers could also meet witty spiders, grumpy demons, and all kinds of supernatural beings.
7 Megumin - KonoSuba: God's Blessing On This Wonderful World!
While every KonoSuba character has a good sense of humor, none of them are as charming and amusing as Megumin. She's a fan-favorite character for many reasons, one of which is her laugh-out-loud funny obsession with explosions. This lovable Explosion Mage not only loves her power, but she also has to use it at least once a day if she doesn't want to die.
Megumin can be overly dramatic and stubborn, and she often casts her explosion spell at the worst possible times. It doesn't help that Megumin can only cast one spell a day and will become completely exhausted, which also led to plenty of hilarious moments in KonoSuba: God's Blessing On This Wonderful World!. Despite her childish behavior, Megumin does have a more serious demeanor as well as deadpan delivery which further enhances her comedic appeal.
6 Stephanie Dola - No Game, No Life
No Game, No Life is one of the most underrated Isekai anime series with a wide range of unique and entertaining characters. Even though Stephanie Dola might not be as intelligent as the show's two lead characters, she still plays an important part in the story as she is the granddaughter of the previous king of Imanity.
She's one of the quirkiest characters in the anime who struggles with Sora and Shiro's methods and shows her emotions in a highly exaggerated way, providing plenty of comedic relief throughout the story. While Stephanie was friendly, she also had prideful nature and would try and keep up with Shiro and Sora, which always led to laugh-out-loud funny scenarios.
5 Kumoko - So I'm a Spider, So What?
In Isekai anime the funniest female characters aren't always human-like. Kumoko is one of the funniest Isekai protagonists who reincarnated in a fantasy world and found herself in a pretty unfortunate body too since she became a rather terrifying-looking spider.
However, Kumoko didn't lose her sense of humor or will to survive, so she embarked on a hilarious and dangerous journey to make a life for herself as a spider. So I'm a Spider, So What?'s most hilarious situations are rather absurd but thanks to Kumoko's dry wit and perfectly timed sarcastic comments never fails to make viewers laugh. Since Kumoko manages to both overestimate her own abilities as well as underestimate her opponents, fans can enjoy plenty of humorous mishaps while watching the show.
4 Sumika Fujimiya - Uncle From Another World
Uncle From Another World was one of the funniest anime of 2022 with weird and hilarious characters. Sumika Fujimiya's character has hilarious facial expressions and is not only a childhood friend of Takafumi, but she also has a secret crush on the boy.
Fujimiya soon found out about Ojisan's powerful magical ability and started watching replays of Ojisan's adventures in the other world with Takafumi. Sumika has plenty of hilarious comments and laugh-out-loud funny reactions to Ojisan's attempts to adapt to the modern world again as well as to his wild and interesting memories of the magical world he lived in for so long.
3 Milim Nava - That Time I Got Reincarnated As A Slime
Milim Nava is one of the most impulsive characters in That Time I Got Reincarnated As A Slime who is also an incredibly powerful demon and becomes the best friend of Rimuru Tempest. Thanks to her childlike personality and extreme reactions to certain situations, she created many of the anime's funniest moments.
Since Milim has immense powers but a rather playful demeanor she often creates awkward situations and misunderstandings during her adventures with Rimuru. Milim also makes a few humorous observations as she learns more about the social norms and customs of the human world thanks to Rimuru.
2 Emi Yusa - The Devil Is A Part-Timer!
While Emi Yusa is one of the strictest and strongest characters in The Devil Is A Part-Timer!. She has a no-nonsense attitude and a tendency to be easily annoyed by other characters, which led to some of the anime's most laugh-out-loud funny moments.
Since Emi is the one who had to defeat Satan she often struggled with her beliefs because of Satan's unexpectedly kind and helpful nature. Emi also had hilarious reactions to other characters' schemes and had unforgettably funny interactions with them. She was not only entertaining but also the show's most relatable character whose dedication to defeating Satan made the story much more enjoyable.
1 Clara Valac - Welcome to Demon School! Iruma-kun
Clara Valac is Iruma's eccentric and fiercely loyal friend who is also Welcome to Demon School! Iruma-kun's funniest character. She has a rather unpredictable behavior and a taste for all things unusual and bizarre.
However, Clara not only loves unusual things but often acts in rather odd but highly endearing and hilarious ways too. She also tends to be theatrical and overly dramatic, and she's never afraid to take extreme actions to help out her friends, especially Iruma. Clara is also Babyls Demon School's most mischievous student, whose wacky personality adds a unique flavor to the anime.